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Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig
In addition, over 100 neuroactive peptides (i.e., many of these are co-released along with a small-molecule) transmitters have been found and are commonly thought to have essential functions in controlling essential systems such as reproduction, development, growth, energy homeostasis, cardiovascular activity, and stress response, thus animal physiology in general [34,35]
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